Stephen L Archer Selected Research

Pyruvate Dehydrogenase Acetyl-Transferring Kinase

1/2020	Epigenetic Metabolic Reprogramming of Right Ventricular Fibroblasts in Pulmonary Arterial Hypertension: A Pyruvate Dehydrogenase Kinase-Dependent Shift in Mitochondrial Metabolism Promotes Right Ventricular Fibrosis.
6/2014	The right ventricle in pulmonary arterial hypertension: disorders of metabolism, angiogenesis and adrenergic signaling in right ventricular failure.
3/2013	FOXO1-mediated upregulation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate.
1/2010	The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.
2/2008	Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.
1/2007	A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

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Stephen L Archer Research Topics

Disease

35	Pulmonary Arterial Hypertension 01/2022 - 10/2003
24	Hypoxia (Hypoxemia) 01/2022 - 06/2002
24	Pulmonary Hypertension 01/2022 - 01/2002
14	Neoplasms (Cancer) 01/2022 - 06/2005
11	Vascular Diseases (Vascular Disease) 01/2022 - 01/2010
10	Vascular Remodeling 10/2020 - 12/2006
8	Hypertrophy 01/2022 - 06/2005
7	Fibrosis (Cirrhosis) 01/2022 - 04/2015
7	Heart Failure 01/2020 - 03/2004
7	Inflammation (Inflammations) 01/2020 - 10/2012
7	Ischemia 01/2017 - 03/2004
6	Right Ventricular Hypertrophy 03/2013 - 10/2007
4	Right Ventricular Dysfunction 01/2022 - 04/2013
4	Lung Diseases (Lung Disease) 01/2019 - 10/2005
3	Microvascular Rarefaction 10/2020 - 10/2013
3	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 08/2003
3	Reperfusion Injury 01/2020 - 01/2014
3	Pneumonia (Pneumonitis) 12/2016 - 12/2013
3	Major Depressive Disorder (Major Depressive Disorders) 07/2004 - 08/2003
2	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2020
2	Cardiac Sudden Death (Sudden Cardiac Arrest) 01/2020 - 02/2015
2	Heart Arrest (Cardiac Arrest) 01/2020 - 02/2015
2	Cardiogenic Shock 01/2020 - 12/2016
2	Necrosis 01/2020 - 02/2015
2	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019 - 12/2016
2	Atrial Fibrillation 01/2019 - 02/2009
2	Chronic Obstructive Pulmonary Disease (COPD) 01/2017 - 12/2016
2	Familial Primary Pulmonary Hypertension 01/2016 - 11/2010
2	Connective Tissue Diseases (Connective Tissue Disease) 10/2012 - 02/2010
2	Thrombosis (Thrombus) 10/2012 - 01/2003
2	Patent Ductus Arteriosus 02/2008 - 09/2004
2	Coronary Disease (Coronary Heart Disease) 01/2005 - 12/2003
2	Hypotension (Low Blood Pressure) 01/2005 - 03/2004
2	Erectile Dysfunction 09/2004 - 01/2002
1	Cardiotoxicity 01/2022
1	Chest Pain (Chest Pains) 05/2021
1	Lung Neoplasms (Lung Cancer) 01/2021

Drug/Important Bio-Agent (IBA)

12	MonocrotalineIBA 01/2022 - 04/2007
11	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2012
10	Oxygen (Dioxygen)IBA 01/2021 - 09/2004
8	Dynamins (Dynamin)IBA 01/2021 - 05/2012
7	Glucose (Dextrose)FDA LinkGeneric 10/2020 - 01/2007
6	Pyruvate Dehydrogenase Acetyl-Transferring KinaseIBA 01/2020 - 01/2007
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 05/2011 - 01/2003
5	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 11/2020 - 06/2005
5	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 06/2006
5	CalciumIBA 01/2019 - 12/2006
4	Vasodilator Agents (Vasodilators)IBA 01/2020 - 11/2010
4	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 03/2013
4	superoxide dismutase 2IBA 01/2016 - 06/2010
4	Transcription Factors (Transcription Factor)IBA 01/2013 - 02/2008
4	Sildenafil Citrate (Viagra)FDA Link 05/2011 - 10/2003
3	Semaxinib (SU5416)IBA 01/2022 - 03/2012
3	Pyruvate KinaseIBA 01/2022 - 12/2017
3	Protein Isoforms (Isoforms)IBA 01/2022 - 01/2018
3	Ion Channels (Ion Channel)IBA 01/2021 - 01/2016
3	EnzymesIBA 01/2021 - 01/2016
3	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 10/2020 - 09/2002
3	RotenoneIBA 01/2019 - 06/2002
3	CreatinineIBA 01/2019 - 05/2008
3	PotassiumIBA 01/2016 - 07/2007
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2014 - 10/2005
3	SurvivinIBA 01/2013 - 06/2005
3	Epoprostenol (Prostacyclin)FDA LinkGeneric 10/2012 - 11/2010
2	pro-brain natriuretic peptide (1-76)IBA 10/2020 - 01/2019
2	Biomarkers (Surrogate Marker)IBA 10/2020 - 09/2018
2	CollagenIBA 01/2020 - 01/2018
2	Pyruvic Acid (Pyruvate)IBA 01/2020 - 03/2013
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2020 - 01/2019
2	Carbon MonoxideIBA 01/2019 - 02/2010
2	Interleukin-6 (Interleukin 6)IBA 01/2019 - 01/2018
2	riociguatIBA 01/2018 - 07/2013
2	rho-Associated KinasesIBA 01/2017 - 04/2007
2	DNA (Deoxyribonucleic Acid)IBA 01/2016 - 10/2013
2	Adrenergic Agents (Adrenergic Drugs)IBA 06/2014 - 12/2012
2	GadoliniumIBA 02/2012 - 11/2011
2	Phosphodiesterase 5 InhibitorsIBA 11/2009 - 07/2007
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 07/2007 - 07/2006
2	Potassium Channels (Potassium Channel)IBA 07/2007 - 01/2002
2	Voltage-Gated Potassium Channels (Voltage-Gated Potassium Channel)IBA 06/2006 - 01/2002
2	NitratesIBA 01/2005 - 03/2004
2	Paroxetine (Paxil)FDA LinkGeneric 12/2003 - 08/2003
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2022
1	Cisplatin (Platino)FDA LinkGeneric 01/2022
1	InflammasomesIBA 01/2022
1	Atrial Natriuretic Factor (ANF)IBA 01/2022
1	shikoninIBA 01/2022
1	N'- (7- fluoroH- pyrrolo(1,2- a)quinoxalin- 4- yl)pyrazine- 2- carbohydrazideIBA 01/2022
1	N- (1,2,3,5,6,7- hexahydro- S- indacen- 4- ylcarbamoyl)- 4- (2- hydroxy- 2- propanyl)- 2- furansulfonamideIBA 01/2022
1	Carvedilol (Coreg)FDA LinkGeneric 01/2021
1	Serine (L-Serine)FDA Link 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021

Therapy/Procedure

23	Therapeutics 01/2022 - 12/2004
3	Anesthesia 02/2006 - 12/2004
2	Heterologous Transplantation (Xenotransplantation) 01/2021 - 05/2012
2	Resuscitation 01/2020 - 02/2015
2	Cardiopulmonary Resuscitation (CPR) 01/2020 - 02/2015
2	Drug Therapy (Chemotherapy) 08/2010 - 09/2004
1	Percutaneous Coronary Intervention 05/2021
1	Precision Medicine 01/2021